We have found that plasma exosomes are one of the ways by which radiation can affect bone metabolism and regeneration. However, the specific mechanisms of how these plasma exosomal miRNAs mediate the osteogenesis pathways must be further investigated. Clinical Relevance. Radiotherapy may cause radiation bone injury, and miRNA expression levels in rabbit plasma exosomes are altered after radiotherapy. High-throughput RNA sequencing can identify the differentially expressed miRNAs in irradiated plasma exosomes during the process of osteogenesis. These findings make sense to develop novel therapeutic strategies for treating radiation-induced bone injury disorders.
Keyphrases
- radiation induced
- stem cells
- mesenchymal stem cells
- radiation therapy
- high throughput
- bone regeneration
- peripheral blood
- bone mineral density
- poor prognosis
- early stage
- single cell
- squamous cell carcinoma
- soft tissue
- body composition
- binding protein
- bone marrow
- high resolution
- nitric oxide
- single molecule
- long non coding rna
- atomic force microscopy
- visible light