Systematic Review: White Matter Microstructural Organization in Adolescents With Depression.
Petya D RadoevaVictor T MilevJeffrey I HuntChristopher H LegereSean C L DeoniStephen J SheinkopfCarla A MazefskyNoah S PhilipDaniel P DicksteinPublished in: JAACAP open (2023)
Our systematic review suggests aberrant white matter microstructure in limbic-cortical-striatal-thalamic circuits, and the corpus callosum, in adolescents with depression. Future research should focus on developmental trajectories in depression, identifying sources of heterogeneity and integrating findings across imaging modalities.