Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure.
Adeline DivouxKatalin SandorDora BojcsukFanchao YiMeghan E HopfJoshua S SmithBalint L BalintTimothy F OsborneSteven R SmithPublished in: Journal of the Endocrine Society (2020)
Integration of data from all 3 approaches suggests that chromatin openness partially governs the transcriptome of gluteofemoral adipocytes and may be involved in the early metabolic syndrome predisposition associated with body shape.
Keyphrases
- genome wide
- metabolic syndrome
- gene expression
- adipose tissue
- dna methylation
- single cell
- dna damage
- rna seq
- transcription factor
- polycystic ovary syndrome
- insulin resistance
- electronic health record
- uric acid
- pregnancy outcomes
- cardiovascular risk factors
- cervical cancer screening
- fatty acid
- pregnant women
- cardiovascular disease
- deep learning