Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis.
Hyo-Jung KimByung-Hak KimBo-Ram JinSang Jae ParkHyo-Jin AnPublished in: Journal of agricultural and food chemistry (2022)
Purple corn ( Zea mays L.), utilized as a natural pigment in food production and processing, has been used to treat obesity, cystitis, and urinary tract infections. However, no reports of its use for benign prostatic hyperplasia (BPH) exist. Purple corn extract (PCE) contains anthocyanins, particularly cyanidin-3- O -glucoside, which have various pharmacological characteristics. Therefore, this study sought to elucidate the ameliorative effect of PCE on BPH in dihydrotestosterone (DHT)-stimulated WPMY-1 cells and testosterone propionate (TP)-induced rats. Expression levels of the upregulated androgen receptor (AR) and its related genes in DHT-stimulated WPMY-1 cells were reduced by PCE, and proapoptotic gene expression increased by modulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling cascade. PCE reduced the weight of the enlarged prostate by inhibiting the androgen/AR signaling-related markers. Histological variations in the prostate epithelium caused by TP injection were restored by PCE. Thus, PCE alleviates BPH by modulating prostate cell proliferation and apoptosis.
Keyphrases
- benign prostatic hyperplasia
- cell cycle arrest
- lower urinary tract symptoms
- pi k akt
- cell proliferation
- signaling pathway
- induced apoptosis
- oxidative stress
- cell death
- endoplasmic reticulum stress
- gene expression
- protein kinase
- urinary tract infection
- weight loss
- type diabetes
- poor prognosis
- metabolic syndrome
- prostate cancer
- body mass index
- cell cycle
- weight gain
- emergency department
- dna methylation
- skeletal muscle
- anti inflammatory
- high glucose
- ultrasound guided
- drug induced
- risk assessment
- endothelial cells
- binding protein
- body weight
- replacement therapy
- long non coding rna