Monitoring Apoptosis and Myeloid Differentiation of Acridine Orange-Mediated Sonodynamic Therapy-Induced Human Promyelocytic Leukemia HL60 Cells.
Metin ÇalişkanRahsan Ilıkcı SagkanGülsen BayrakSerçin Özlem ÇalışkanPublished in: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine (2024)
Data showed that AO-mediated SDT significantly induced apoptosis in HL60 cells. Increased expression of CD11b and CD15 antigens and morphological findings demonstrated that AO-mediated SDT contributes to granulocytic differentiation in HL60 cells. AO-mediated SDT has potential as an alternative treatment of APL.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- cell cycle arrest
- oxidative stress
- signaling pathway
- cell death
- acute myeloid leukemia
- endothelial cells
- bone marrow
- dendritic cells
- poor prognosis
- stem cells
- machine learning
- mesenchymal stem cells
- deep learning
- combination therapy
- nk cells
- induced pluripotent stem cells