Antimicrobial Hydrogels: Potential Materials for Medical Application.
Yanni LiYujia HanHongxia LiXiaohui NiuDeyi ZhangKunjie WangPublished in: Small (Weinheim an der Bergstrasse, Germany) (2023)
Microbial infections based on drug-resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from trauma worldwide. The prevalence of drug-resistant pathogens has led to a significant increase in medical costs and poses a great threat to the normal life of people. This is an important issue in the field of biomedicine, and the emergence of new antimicrobial materials hydrogels holds great promise for solving this problem. Hydrogel is an important material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self-healing, corrosion resistance, and controlled release of drugs as well as structural diversity. Bacteria-disturbing hydrogels have important applications in the direction of surgical treatment, wound dressing, medical device coating, and tissue engineering. This paper reviews the classification of antimicrobial hydrogels, the current status of research, and the potential of antimicrobial hydrogels for one application in biomedicine, and analyzes the current research of hydrogels in biomedical applications from five aspects: metal-loaded hydrogels, drug-loaded hydrogels, carbon-material-loaded hydrogels, hydrogels with fixed antimicrobial activity and biological antimicrobial hydrogels, and provides an outlook on the high antimicrobial activity, biodegradability, biocompatibility, injectability, clinical applicability and future development prospects of hydrogels in this field.
Keyphrases
- tissue engineering
- drug delivery
- wound healing
- hyaluronic acid
- drug resistant
- drug release
- extracellular matrix
- current status
- staphylococcus aureus
- multidrug resistant
- healthcare
- minimally invasive
- acinetobacter baumannii
- systematic review
- randomized controlled trial
- escherichia coli
- climate change
- acute coronary syndrome
- risk assessment
- risk factors
- artificial intelligence
- antimicrobial resistance