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Effectiveness of seasonal malaria chemoprevention (SMC) treatments when SMC is implemented at scale: Case-control studies in 5 countries.

Matthew E CairnsSerign Jawo CeesayIssaka SagaraIssaka ZongoHamit KesselyKadidja GamougamAbdoulaye DialloJohnbull Sonny OgboiDiego MorosoSuzanne Van HulleTony EloikePaul SnellSusana ScottCorinne Simone Collette MerleKalifa BojangJean-Bosco OuedraogoAlassane DickoJean Louis Abdourahim NdiayePaul Milligan
Published in: PLoS medicine (2021)
SMC administered as part of routine national malaria control activities provided a very high level of personal protection against clinical malaria over 28 days post-treatment, similar to the efficacy observed in clinical trials. The case-control design used in this study can be used at intervals to ensure SMC treatments remain effective.
Keyphrases
  • case control
  • plasmodium falciparum
  • clinical trial
  • randomized controlled trial
  • systematic review
  • clinical practice
  • quality improvement
  • combination therapy
  • phase iii
  • smoking cessation