ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia.
Carl J FisherCarolyn NiuWarren FoltzYonghong ChenElena Sidorova-DarmosJames H EubanksLothar LilgePublished in: PloS one (2017)
The benefits of hypothermia on both normal neuronal tissue as well as increased PpIX fluorescence and RG2 induced rat survival strongly suggest a role for hypothermia in photonics-based surgical techniques, and that a hypothermic intervention could lead to considerable patient outcome improvements.