Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles.
Eilis J HannonEmma L DempsterJonathan P DaviesBarry ChiozaGeorgina E T BlakeJoe BurrageStefania PolicicchioAlice FranklinEmma M WalkerRosemary A BamfordLeonard C SchalkwykJonathan MillPublished in: BMC biology (2024)
Our novel deconvolution models produce accurate estimates for cell proportions in the human cortex. These models are available as a resource to the community enabling the control of cellular heterogeneity in epigenetic studies of brain disorders performed on bulk cortex tissue.