Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis.
Alaleh GhasemiAli FarazmandVahideh HassanzadehShiva PoursaniSamaneh SoltaniMaryam AkhtariMaassoumeh AkhlaghiElham FarhadiAhmadreza JamshidiMahdi MahmoudiPublished in: Clinical rheumatology (2022)
Collectively, our results suggest that upregulated expression of KAT2B and ESCO2 genes may be correlated to RA development. Further studies with larger sample sizes are required for understanding the potential contribution of these enzymes in the pathology of RA. Key Points • Dysregulated expression level of epigenetics enzymes was observed in PBMCs from RA patients. • The expression of KAT2B was 2.44 times higher in the PBMCs of RA patients than in the healthy subjects. • The expression of ESCO2 was upregulated (2.75 times) in the PBMCs of RA patients compared to the control group. • There was a positive correlation between ESCO2 expression and the ESR level in patients.
Keyphrases
- end stage renal disease
- poor prognosis
- gene expression
- newly diagnosed
- ejection fraction
- rheumatoid arthritis
- peritoneal dialysis
- cell proliferation
- patient reported outcomes
- disease activity
- signaling pathway
- ankylosing spondylitis
- climate change
- transcription factor
- systemic sclerosis
- idiopathic pulmonary fibrosis