Respiratory syncytial virus exhibits differential tropism for distinct human placental cell types with Hofbauer cells acting as a permissive reservoir for infection.
Vladimir BokunJohn J MooreRobert MooreCarrie C SmallcombeTerri J HarfordFariba RezaeeFrank P EsperGiovanni PiedimontePublished in: PloS one (2019)
This study demonstrates that RSV can replicate in human placenta, exhibits differential tropism for distinct placental cell types, can be stored and transferred to neighboring cells by Hofbauer cells, and elicits an inflammatory response. It also supports the hypothesis that this respiratory virus can be vertically transferred to the fetus and potentially affect its development and the outcome of pregnancies.
Keyphrases
- induced apoptosis
- cell cycle arrest
- inflammatory response
- respiratory syncytial virus
- endothelial cells
- single cell
- cell therapy
- endoplasmic reticulum stress
- signaling pathway
- cell death
- pregnant women
- lipopolysaccharide induced
- mesenchymal stem cells
- pi k akt
- respiratory tract
- room temperature
- lps induced
- pluripotent stem cells