Aerobic exercise protects MI heart through miR-133a-3p downregulation of connective tissue growth factor.

Niu LiuZhiping ZhenXin XiongYaqi Xue

Published in: PloS one (2024)

Aerobic exercise down-regulated CTGF expression in MI mouse myocardium through miR-133a-3p, thereby inhibiting cardiomyocyte apoptosis and improving cardiac function.

Keyphrases

growth factor
signaling pathway
poor prognosis
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
heart failure
cell proliferation
cell death
transcription factor
angiotensin ii
binding protein