5α-reductase 1 mRNA levels are positively correlated with TRAMP mouse prostate most severe lesion scores.

Alexander B Opoku-AcheampongJamie N HenningsonAmanda P BeckBrian L Lindshield

Published in: PloS one (2017)

Downregulation of androgen receptor and 5α-reductase 2, along with upregulation of 5α-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice.

Keyphrases

prostate cancer
radical prostatectomy
high grade
benign prostatic hyperplasia
cell proliferation
signaling pathway
poor prognosis
high fat diet induced
metabolic syndrome