Identification of TMZ resistance-associated histone post-translational modifications in glioblastoma using multi-omics data.
Liguo YeLingui GuYaning WangHao XingPengtao LiXiaopeng GuoYu WangWenbin Ma
Published in: CNS neuroscience & therapeutics (2024)
The increase in H3K9ac appears to enhance the recruitment of the transcription factor SP1 to its binding sites within the MGMT locus, consequently upregulating MGMT expression and driving TMZ resistance in GBM.