Light-Enhanced O2-Evolving Nanoparticles Boost Photodynamic Therapy To Elicit Antitumor Immunity.
Tingting WangHao ZhangYaobao HanHanghang LiuFeng RenJianfeng ZengQiao SunZhen LiMingyuan GaoPublished in: ACS applied materials & interfaces (2019)
Breast cancer remains to show high mortality and poor prognosis in women despite of significant progress in recent diagnosis and treatment. Herein, we report the rational design of a highly efficient ultrasmall nanotheranostic agent with excellent photodynamic therapy (PDT) performance to against breast cancer and its metastasis by eliciting antitumor immunity. The ultrasmall nanoagent (3.1 ± 0.4 nm) was fabricated from polyethylene glycol modified Cu2- xSe nanoparticles, β-cyclodextrin, and chlorin e6 under ambient conditions. The resultant nanoplatform (CS-CD-Ce6 NPs) can be passively accumulated into the tumor to exhibit dramatic antitumor efficacy through the excellent PDT effect under near-infrared irradiation. The excellent PDT performance of this nanoplatform is owing to its role as a Fenton-like Haber-Weiss catalyst for the efficient degradation of H2O2 within the tumor to release hydroxyl radicals (·OH) and very toxic singlet oxygen (1O2) under irradiation. The generated vast amounts of reactive oxygen species not only killed primary tumor cells but also elicited immunogenic cell death (ICD) to release damage-associated molecular patterns (DAMPs) and induced proinflammatory M1-macrophages polarization. Thereby, antitumor immune responses against the metastasis of breast cancer were robustly evoked. Our work demonstrates that ultrasmall Cu2- xSe nanoparticle-based nanoplatform offers a promising way to prevent cancer metastasis via immunogenic effects through its excellent PDT performance.
Keyphrases
- reduced graphene oxide
- photodynamic therapy
- poor prognosis
- highly efficient
- fluorescence imaging
- cell death
- iron oxide
- immune response
- reactive oxygen species
- long non coding rna
- breast cancer risk
- oxidative stress
- type diabetes
- cardiovascular events
- polycystic ovary syndrome
- papillary thyroid
- air pollution
- metabolic syndrome
- radiation therapy
- cardiovascular disease
- radiation induced
- high glucose
- wastewater treatment
- ionic liquid
- particulate matter
- room temperature
- quantum dots
- cancer therapy
- diabetic rats
- endothelial cells
- cell cycle arrest