Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway.

Takashi MiwaMitsuro KandaDai ShimizuShinichi UmedaKoichi SawakiHaruyoshi TanakaChie TanakaNorifumi HattoriMasamichi HayashiSuguru YamadaGoro NakayamaMasahiko KoikeYasuhiro Kodera

Published in: British journal of cancer (2021)

Upregulation of ETNK2 in GC enhances hepatic metastasis, possibly via dysregulation of p53-Bcl-2-associated apoptosis. ETNK2 expression may serve as a biomarker for predicting hepatic recurrence and a therapeutic target.

Keyphrases

poor prognosis
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell death
long non coding rna
binding protein
cell proliferation
signaling pathway