The WIRE study a phase II, multi-arm, multi-centre, non-randomised window-of-opportunity clinical trial platform using a Bayesian adaptive design for proof-of-mechanism of novel treatment strategies in operable renal cell cancer - a study protocol.
Stephan UrsprungHelen MossopFerdia A GallagherEvis SalaRichard SkellsJamal A N SippleThomas J MitchellAnita ChhabraKate FifeAthena MatakidouGemma YoungAmanda WalkerMartin G ThomasMireia Crispin OrtuzarMark SullivanAndrew ProtheroeGrenville OadesBalaji VenugopalAnne Y WarrenJohn StoneTim EisenJames WasonSarah J WelshGrant D StewartPublished in: BMC cancer (2021)
ClinicalTrials.gov: NCT03741426 / EudraCT: 2018-003056-21 .