Distal pancreatectomy with en bloc celiac axis resection for pancreatic cancer: a pooled analysis of 109 cases.
Jianfa LanYufeng ChenShijie WangYanming ZhouPublished in: Updates in surgery (2020)
The aim of this study was to define the clinical outcome and prognostic determinants of distal pancreatectomy with en bloc celiac axis resection (DP-CAR) for pancreatic body/tail cancer. A pooled data analysis was performed on individual data for patients who underwent DP-CAR for pancreatic body/tail cancer as identified by systematic literature search. A total of 32 articles involving 109 patients were eligible for inclusion. Postoperative morbidity and mortality were 53% and 4%, respectively. Preoperative abdominal and/or back pain was completely relieved immediately after surgery in 98% of patients. The 1, 3 and 5 years overall survival (OS) rates were 59%, 21% and 10%, and the median OS was 14 months. Patients who received neoadjuvant treatment had a median OS of 23 months. In conclusion, DP-CAR for locally advanced pancreatic body/tail cancer can be performed safely with low mortality and provides survival benefit when combined with neoadjuvant treatment.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- papillary thyroid
- systematic review
- prognostic factors
- lymph node
- cardiovascular disease
- randomized controlled trial
- squamous cell carcinoma
- rectal cancer
- coronary artery disease
- squamous cell
- patient reported outcomes
- patients undergoing
- minimally invasive
- radiation therapy
- locally advanced
- big data
- young adults
- smoking cessation
- deep learning
- patient reported
- celiac disease