Antioxidant-upregulated mesenchymal stem cells reduce inflammation and improve fatty liver disease in diet-induced obesity.
Cleyton C DominguesNabanita KunduYana KropotovaNeeki AhmadiSabyasachi SenPublished in: Stem cell research & therapy (2019)
Reduction of oxidative stress post-antioxidant-upregulated MSC delivery, intraperitoneally, reduces systemic inflammation and fat accumulation in the liver. There is evidence of an increase in browning of white adipose tissue depots with concomitant improvement of glucose tolerance in a weight-independent fashion. Antioxidant-upregulated MSC delivery may be a safe yet effective therapy for obesity and prediabetes and improves related complication such as non-alcoholic fatty liver disease.
Keyphrases
- oxidative stress
- adipose tissue
- insulin resistance
- weight loss
- high fat diet induced
- mesenchymal stem cells
- weight gain
- metabolic syndrome
- diabetic rats
- dna damage
- type diabetes
- anti inflammatory
- ischemia reperfusion injury
- induced apoptosis
- high fat diet
- body mass index
- umbilical cord
- fatty acid
- stem cells
- skeletal muscle