Association of polygenic risk score with response to deep brain stimulation in Parkinson's disease.

Esther YoonSarah AhmedRyan LiSara Bandres-CigaCornelis BlauwendraatIrene DustinSonja ScholzMark HallettDebra Ehrlich

Published in: BMC neurology (2023)

This exploratory study suggests that PRS may predict degree of improvement in depressive symptoms after DBS, though was not predictive of motor and other cognitive outcomes after DBS. Additionally, PRS may be most relevant in predicting DBS outcomes in patients lacking pathogenic or high-risk PD variants. However, this was a small preliminary study and response to DBS treatment is multifactorial, therefore, more standardized high-powered studies are needed.

Keyphrases

deep brain stimulation
parkinson disease
obsessive compulsive disorder
depressive symptoms
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
type diabetes
skeletal muscle
metabolic syndrome
gene expression
social support
replacement therapy