SARS-CoV-2 serology increases diagnostic accuracy in CT-suspected, PCR-negative COVID-19 patients during pandemic.
Jochen SchneiderHrvoje MijočevićKurt UlmBernhard UlmSimon WeidlichSilvia WürstleKathrin RotheMatthias TreiberRoman IakoubovUlrich MayrTobias LahmerSebastian RaschAlexander HernerEgon BurianFabian LohöferRickmer BrarenMarcus R MakowskiRoland M SchmidUlrike ProtzerChristoph SpinnerFabian GeislerPublished in: Respiratory research (2021)
Approximately one-third of patients with distinct COVID-19 CT findings are tested negative for SARS-CoV-2 RNA by PCR rendering correct diagnosis difficult. Implementation of SARS-CoV-2 serology testing alongside current CT/PCR-based diagnostic algorithms improves discrimination between COVID-19-related and non-related pulmonary infiltrates in PCR negative patients. However, sensitivity of SARS-CoV-2 serology strongly depends on the time of testing and becomes superior to PCR after the 2nd week following symptom onset.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- image quality
- computed tomography
- dual energy
- contrast enhanced
- real time pcr
- end stage renal disease
- chronic kidney disease
- magnetic resonance imaging
- newly diagnosed
- positron emission tomography
- primary care
- ejection fraction
- healthcare
- randomized controlled trial
- pulmonary embolism
- prognostic factors
- deep learning
- patient reported outcomes