Targeted lung denervation modulates the mucosal epithelial transcriptome in COPD.

Karthi SrikanthanLoes KistemakerDirk-Jan Slebos Wolfgang Gesierich Kaid DarwichePeter BontaGaetan DesleePallav L ShahReinoud Gosens

Published in: ERJ open research (2022)

This study shows that TLD reduces airway epithelial expression of genes related to acetylcholine processing and airway inflammation, which may help to elucidate the mechanism for its effect of reducing severe exacerbations in COPD https://bit.ly/3dWcqZk.

Keyphrases

chronic obstructive pulmonary disease
lung function
genome wide
poor prognosis
cystic fibrosis
gene expression
single cell
rna seq
early onset
cancer therapy
transcription factor