CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI.
Hilde van den BrinkAnna KopczakTine ArtsLaurien OnkenhoutJeroen C W SieroJaco J M ZwanenburgSandra HeinMathias HübnerBenno GesierichMarco DueringMichael S StringerJeroen HendrikseJoanna Marguerite WardlawAnne JoutelMartin DichgansGeert Jan Biesselsnull nullPublished in: Annals of neurology (2022)
Multiple aspects of cerebral small vessel function on 7T-MRI were abnormal in CADASIL patients, indicative of increased arteriolar stiffness and regional abnormalities in reactivity, locally also in relation to white matter injury. These observations provide novel markers of cSVD for mechanistic and intervention studies. ANN NEUROL 2022.