Green Approach for Visible-Light-Induced Direct Functionalization of 2-Methylquinolines.

Juliana A DantasRadell EchemendíaMarilia S SantosMárcio Weber PaixãoMarco Antonio B FerreiraArlene Gonçalves Corrêa

Published in: The Journal of organic chemistry (2020)

A transition metal- and oxidant-free visible light-photoinduced protocol for direct functionalization of 2-methylquinolines has been developed. This protocol enabled the C-H functionalization of substituted 2-methylquinolines with diacetyl or ethyl pyruvate, under environmentally friendly conditions. A mechanistic investigation based on density functional theory (DFT) calculations provided details about the origins of reactivity and selectivity.

Keyphrases

visible light
density functional theory
transition metal
molecular dynamics
randomized controlled trial
high glucose
diabetic rats
molecular docking
ionic liquid
anti inflammatory
oxidative stress
electron transfer
low cost