Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug-refractory epilepsy.
Hong-Li GuoWei-Jun WangDong NaZhao Yue-TaoDai Hao-RanHu Ya-HuiZhang Yuan-YuanJie WangQiu Jin-ChunLu Xiao-PengChen FengPublished in: Epilepsia open (2023)
The results of this study suggested an association between FAs metabolism and the medically intractable epilepsy. Such novel findings might propose a potential mechanism linked to the energy metabolism. Ketogenic acid and FAs supplementation might therefore be high priority strategies for DRE management efforts.