Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome.
Davide LucchesiRachel ColebyElena PontariniEdoardo PredilettoFelice RivelleseDavid G HillAlicia Derrac SoriaSimon A JonesIan R HumphreysNurhan SutcliffeAnwar R TappuniCostantino PitzalisGareth W JonesMichele BombardieriPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Our data indicate that the physiologic ability of IL-27 to limit the magnitude and function of ELS through control of Th17 cell expansion is severely impaired in SS patients, highlighting a defective immunoregulatory checkpoint in this condition.