Effectiveness of intramuscular naloxone 1,600 μg in addition to titrated intravenous naloxone 100 μg for opioid poisoning: a randomised controlled trial.

Katherine Z Isoardi Keith Harris Elizabeth Currey Nicholas Alan Buckley Geoffrey K Isbister

Published in: Clinical toxicology (Philadelphia, Pa.) (2024)

The addition of intramuscular naloxone 1,600 µg to titrated intravenous naloxone prolonged effective reversal of respiratory depression, with fewer naloxone doses and infusions given, and no significant difference in patients developing withdrawal.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
randomized controlled trial
high dose
chronic kidney disease
chronic pain
depressive symptoms
prognostic factors
peritoneal dialysis
low dose
patient reported outcomes
physical activity