Metabolic reprogramming and angiogenesis in primary cutaneous Merkel cell carcinoma: expression of hypoxia-inducible factor-1α and its central downstream factors.

Ferdinand Toberer Holger A HaenssleM Heinzel-GutenbrunnerA EnkW HartschuhP HelmboldH Kutzner

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)

Our data provide first evidence for a role of HIF-1α in induced metabolic reprogramming contributing to MCC pathogenesis. The metabolic signatures of McPyV+ and McPyV- tumours seem to show relevant differences.

Keyphrases

endothelial cells
poor prognosis
high glucose
big data
electronic health record
oxidative stress
machine learning
dna methylation
drug induced
deep learning
artificial intelligence
wound healing