CLEC10A is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in lung adenocarcinoma.
Min HeYing HanChangjing CaiPing LiuYihong ChenHong ShenXingyuan XuShan ZengPublished in: Journal of cellular and molecular medicine (2021)
CLEC10A, (C-type lectin domain family 10, member A), as the member of C-type lectin receptors (CLRs), plays a vital role in modulating innate immunity and adaptive immunity and has shown great potential as an immunotherapy target for cancers. However, there is no functional research of CLEC10A in prognostic risk, immunotherapy or any other treatment of lung adenocarcinoma (LUAD). We performed bioinformatics analysis on LUAD data downloaded from TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus), and jointly analysed with online databases such as HPA, LinkedOmics, TIMER, ESTIMATE and TISIDB. We found that lower expression of CLEC10A was accompanied with worse outcomes of LUAD patients. Moreover, CLEC10A expression was significantly correlated with a variety of the tumour-infiltrating immune cells (TIICs). As a promising prognosis predictor and potential immunotherapy target, the potential influence and mechanisms of CLEC10A in LUAD deserve further exploring.
Keyphrases
- gene expression
- poor prognosis
- bioinformatics analysis
- end stage renal disease
- newly diagnosed
- big data
- chronic kidney disease
- long non coding rna
- binding protein
- electronic health record
- risk assessment
- adipose tissue
- papillary thyroid
- type diabetes
- lymph node
- machine learning
- patient reported outcomes
- signaling pathway
- weight loss
- lymph node metastasis
- data analysis