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SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.

Boris SchminkePhilipp KauffmannAndrea SchubertManuel AltherrThomas GelisNicolai Miosge
Published in: Cartilage (2020)
This study shows that SMURF1 and SMURF2 are regulatory players for the expression of the major regulator transcription factors RUNX2 and SOX9 in CPCs and MPCs. Our novel findings may help elucidate new treatment strategies for cartilage regeneration.
Keyphrases
  • transcription factor
  • stem cells
  • dna binding
  • poor prognosis
  • rheumatoid arthritis
  • genome wide identification
  • knee osteoarthritis
  • extracellular matrix
  • wound healing