Intravenous ibuprofen for acute treatment of migraine: A double-blind, randomized, placebo-controlled pilot study.
Hsiangkuo YuanJohn G CurranScott W KeithMary M HopkinsStephen D SilbersteinPublished in: Headache (2021)
This study did not meet the primary endpoint but showed pain relief and elimination of several associated symptoms within 2 h on repeated-measures analysis. Although limited by small sample size and high placebo response, our results indicate that IV ibuprofen may be a safe and effective option for acute treatment of migraine, but more extensive studies are necessary.
Keyphrases
- placebo controlled
- double blind
- liver failure
- chronic pain
- respiratory failure
- open label
- pain management
- randomized controlled trial
- combination therapy
- squamous cell carcinoma
- phase ii
- hepatitis b virus
- spinal cord injury
- spinal cord
- acute respiratory distress syndrome
- sleep quality
- smoking cessation
- locally advanced