Cell-based therapies for retinal diseases: a review of clinical trials and direct to consumer "cell therapy" clinics.
John W HinkleRaziyeh MahmoudzadehAjay E KuriyanPublished in: Stem cell research & therapy (2021)
Currently, there are no proven effective cell-based treatments for retinal diseases, although several trials have investigated potential therapies. These studies reported favorable safety profiles with multiple surgical approaches, with cells derived from multiple sources, and with utilized different immunosuppressive regiments. However, data demonstrating the efficacy and long-term safety are still pending. Nevertheless, "cell therapy" clinics continue to conduct direct-to consumer marketing for non-FDA-approved treatments with potentially blinding complications.
Keyphrases
- cell therapy
- stem cells
- mesenchymal stem cells
- clinical trial
- optical coherence tomography
- primary care
- diabetic retinopathy
- induced apoptosis
- health information
- single cell
- randomized controlled trial
- healthcare
- electronic health record
- cell cycle arrest
- optic nerve
- machine learning
- high resolution
- cell death
- open label
- high speed
- case control