Development of pH-Sensitive Nanoparticle Incorporated into Dissolving Microarray Patch for Selective Delivery of Methotrexate.

Nur Qadri FebriantiAnugerah Yaumil Ramadhani AzizMuhamad Gilang Ramadhan TunggengIndianty Dwi RamadhanyNur SyafikaSumayya Binti Abd AzisYulia Yusrini DjabirRangga Meidianto AsriAndi Dian Permana

Published in: AAPS PharmSciTech (2024)

The developed SNP-DMAP-MTX has been proven to deliver MTX transdermal and selectively at the RA site, potentially avoiding conventional MTX side effects and enhancing the effectiveness of RA therapy.

Keyphrases

rheumatoid arthritis
disease activity
randomized controlled trial
systematic review
ankylosing spondylitis
genome wide
high dose
interstitial lung disease
stem cells
systemic lupus erythematosus
low dose
mesenchymal stem cells
systemic sclerosis
cell therapy
idiopathic pulmonary fibrosis
replacement therapy