Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells.
Haifeng FuWeiyu ZhangNiannian LiJiao YangXiaoying YeChenglei TianXinyi LuLin LiuPublished in: Genome biology (2021)
Our data suggest that fragile telomere, retrotransposon-associated genomic instability, and declined DNA recombination repair, together with reduced function of cell cycle and mitochondria, increased apoptosis, and differentiation properties may link to compromised developmental potency of primed PSCs, noticeably distinguishable from naïve PSCs.
Keyphrases
- cell cycle
- pluripotent stem cells
- cell proliferation
- cell death
- copy number
- oxidative stress
- cell cycle arrest
- circulating tumor
- endoplasmic reticulum stress
- electronic health record
- single molecule
- dna damage
- cell free
- dna repair
- big data
- reactive oxygen species
- dna methylation
- gene expression
- machine learning
- genome wide