MicroRNAs modulation and clinical outcomes at 1 year of follow-up in obese patients with pre-diabetes treated with metformin vs. placebo.
Celestino SarduMaria Consiglia TrottaGorizio PierettiGianluca GattaGiuseppe FerraroGiovanni Francesco NicolettiNunzia D' OnofrioMaria Luisa BalestrieriMichele D' AmicoAngela AbbatecolaFranca FerraraccioIacopo PanareseGiuseppe PaolissoRaffaele MarfellaPublished in: Acta diabetologica (2021)
In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT.
Keyphrases
- obese patients
- oxidative stress
- bariatric surgery
- cell proliferation
- long non coding rna
- gastric bypass
- roux en y gastric bypass
- long noncoding rna
- type diabetes
- glycemic control
- weight loss
- cardiovascular disease
- induced apoptosis
- diabetic rats
- randomized controlled trial
- metabolic syndrome
- newly diagnosed
- heat stress