Clinical effectiveness outcomes and healthcare resource utilization of patients diagnosed with small-cell lung cancer.
Junji LinSantosh GautamNan HuGboyega AdeboyejeSumesh KachrooPublished in: Future oncology (London, England) (2020)
Background: Real-world data are lacking on patients with small-cell lung cancer (SCLC) with extensive-stage SCLC (eSCLC) and poor performance status (PS). Patients & methods: Eligible patients diagnosed with eSCLC between 1 January 2008 and 31 December 2017 were included in this retrospective, observational study. Results: The study included 406 patients, with 14.3% impaired PS. Progression-free survival and overall survival were not significantly different between impaired (Eastern Cooperative Oncology Group ≥2) and not impaired patients (median, 4.5 vs 5.3 months, and 7.2 vs 8.4 months, respectively). Impaired patients used more supportive care drugs (mean, 3.0 vs 2.0; p = 0.033). Conclusion: Effectiveness outcomes among patients with and without impaired PS did not differ in the real-world setting. Progression-free survival and overall survival were similar to data from clinical trials.
Keyphrases
- end stage renal disease
- small cell lung cancer
- healthcare
- ejection fraction
- newly diagnosed
- clinical trial
- chronic kidney disease
- free survival
- randomized controlled trial
- patient reported outcomes
- big data
- insulin resistance
- artificial intelligence
- quality improvement
- social media
- electronic health record
- chronic pain
- drug induced
- placebo controlled