Six-month prospective trial in early and long-standing rheumatoid arthritis: evaluating disease activity in the wrist through sequential synovial histopathological analysis, RAMRIS magnetic resonance score and EULAR-OMERACT ultrasound score.
Søren Andreas JustChristian NielsenJens Christian WerlinrudPia Veldt LarsenCamilla Schufri KlinkbyHenrik Daa SchrøderFran HumbyTrine TorfingHanne LindegaardPublished in: RMD open (2019)
The MRI RAMRIS synovitis score and EULAR-OMERACT US scoring system are sensitive measures of histological synovitis in LRA and ERA. After 6 months, this correlation persists in the established RA group, but not in the ERA group. Overall, decreases in MRI/US synovitis are associated with reductions in histological synovitis. The study validates the use of MRI RAMRIS and EULAR-OMERACT US scores as surrogate markers of histological synovitis in established RA and early untreated RA.
Keyphrases
- disease activity
- rheumatoid arthritis
- contrast enhanced
- systemic lupus erythematosus
- magnetic resonance imaging
- ankylosing spondylitis
- magnetic resonance
- rheumatoid arthritis patients
- juvenile idiopathic arthritis
- diffusion weighted imaging
- interstitial lung disease
- computed tomography
- clinical trial
- study protocol
- open label
- phase iii
- ultrasound guided
- phase ii
- contrast enhanced ultrasound