Angiotensin (1-7) delivered orally via probiotic in combination with exercise: Sex dependent influence on healthspan.

Age-related declines in physical and cognitive function can have tremendous, negative impacts on healthspan and quality of life. Therefore, we investigated the potential of utilizing a probiotic treatment to target the renin-angiotensin system (RAS) in conjunction with moderate exercise to ameliorate age-related declines in cognitive and physical function in aged rats. Herein we utilized a genetically-modified probiotic expresses Angiotensin (1-7), which activates a 'complementary' arm of the RAS through binding Mas (AT7) receptors. This process induces several beneficial physiologic effects, including decreased inflammation and enhanced physical/cognitive function. Thus, in this short research report, we suggest the efficacy of this innovative and novel LPA as either an alternative strategy to exercise, or more likely as an adjuvant to moderate exercise, for the prevention of both physical and cognitive decline especially in female rats.