Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model.
Weiyi ZhaoNatalie GasterichTim ClarnerClara VoelzVictoria BehrensCordian BeyerAthanassios FragoulisAdib ZendedelPublished in: Journal of neuroinflammation (2022)
In summary, our in vivo bioluminescence data showed Nrf2-ARE activation during primary phase of SCI. Furthermore, we found that cell specific hyperactivation of Nrf2 was sufficient to protect the spinal cord against injury which indicate a promising therapeutic approach for SCI-treatment.
Keyphrases
- spinal cord injury
- spinal cord
- oxidative stress
- neuropathic pain
- mouse model
- poor prognosis
- diabetic rats
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- single cell
- cell therapy
- electronic health record
- big data
- replacement therapy
- long non coding rna
- machine learning
- data analysis
- artificial intelligence
- heat stress