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Photochemical Difluoromethylation of Quinoxalin-2(1 H )-ones with Difluoroacetic Anhydride and Pyridine N-Oxide.

Ying ZhangYu LiuYi ZhangYaqing ZhuNingning ZhouXia ZhaoKui Lu
Published in: The Journal of organic chemistry (2023)
A novel photochemical difluoromethylation of quinoxalin-2(1 H )-ones under catalyst-free conditions was achieved with difluoroacetic anhydride and pyridine N-oxide. The green and mild reaction conditions as well as readily attainable difluoroacetic anhydride provide a useful protocol to prepare C3-difluoromethylated quinoxalin-2(1 H )-ones.
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