The Role of Long Noncoding RNAs on Male Infertility: A Systematic Review and In Silico Analysis.
Maria-Anna KyrgiafiniTheologia SarafidouZissis MamurisPublished in: Biology (2022)
Male infertility is a complex disorder affecting many couples worldwide. Long noncoding RNAs (lncRNAs) regulate important cellular processes; however, a comprehensive understanding of their role in male infertility is limited. This systematic review investigates the differential expressions of lncRNAs in male infertility or variations in lncRNA regions associated with it. The PRISMA guidelines were used to search Pubmed and Web of Science (1 June 2022). Inclusion criteria were human participants, patients diagnosed with male infertility, and English language speakers. We also performed an in silico analysis investigating lncRNAs that are reported in many subtypes of male infertility. A total of 625 articles were found, and after the screening and eligibility stages, 20 studies were included in the final sample. Many lncRNAs are deregulated in male infertility, and interactions between lncRNAs and miRNAs play an important role. However, there is a knowledge gap regarding the impact of variants found in lncRNA regions. Furthermore, eight lncRNAs were identified as differentially expressed in many subtypes of male infertility. After in silico analysis, gene ontology (GO) and KEGG enrichment analysis of the genes targeted by them revealed their association with bladder and prostate cancer. However, pathways involved in general in tumorigenesis and cancer development of all types, such as p53 pathways, apoptosis, and cell death, were also enriched, indicating a link between cancer and male infertility. This evidence, however, is preliminary. Future research is needed to explore the exact mechanism of action of the identified lncRNAs and investigate the association between male infertility and cancer.
Keyphrases
- prostate cancer
- polycystic ovary syndrome
- systematic review
- cell death
- genome wide identification
- papillary thyroid
- network analysis
- healthcare
- public health
- randomized controlled trial
- end stage renal disease
- genome wide analysis
- molecular docking
- copy number
- chronic kidney disease
- ejection fraction
- adipose tissue
- metabolic syndrome
- transcription factor
- oxidative stress
- dna methylation
- squamous cell
- spinal cord injury
- endothelial cells
- meta analyses
- lymph node metastasis
- drug delivery