Heterogeneous addiction to transforming growth factor-beta signalling in recessive dystrophic epidermolysis bullosa-associated cutaneous squamous cell carcinoma.

J H S DayalS M MasonJ C Salas-AlanisJohn A McGrathR G TaylorJemima E MellerioK BlythA P SouthGareth J Inman

Published in: The British journal of dermatology (2020)

Targeting TGFBR1 kinase activity may have therapeutic benefit in the majority of RDEB cSCCs. However, the potential tumour suppressive role of TGF-β signalling in a subset of RDEB cSCCs necessitates biomarker identification to enable patient stratification before clinical intervention.

Keyphrases

transforming growth factor
squamous cell carcinoma
epithelial mesenchymal transition
randomized controlled trial
case report
intellectual disability
protein kinase
signaling pathway
locally advanced
muscular dystrophy
radiation therapy
autism spectrum disorder
risk assessment
rectal cancer