Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy.
Moritz MessnerSanthosh Kumar GhadgeValentina GoetschAndreas WimmerJakob DörlerGerhard PölzlMarc-Michael ZarubaPublished in: PloS one (2018)
Our data suggest that progerin is upregulated in human DCM hearts and strongly correlates with left ventricular remodeling. Progerin might be involved in progression of heart failure and myocardial aging.
Keyphrases
- left ventricular
- heart failure
- cardiac resynchronization therapy
- endothelial cells
- hypertrophic cardiomyopathy
- acute myocardial infarction
- mitral valve
- aortic stenosis
- left atrial
- cell proliferation
- electronic health record
- poor prognosis
- induced pluripotent stem cells
- acute heart failure
- big data
- atrial fibrillation
- muscular dystrophy
- deep learning
- acute coronary syndrome