Top-Down Glycopeptidomics Reveals Intact Glycomacropeptide is Digested to a Wide Array of Peptides in Human Jejunum.

This study demonstrates that intact CMP (including glycosylated forms) is mostly digested in the human jejunum, releasing a wide array of CMP-derived peptide fragments. Some of the CMP-derived peptides with high homology to known bioactive peptides consistently survived across 3 h of digestion. Therefore, future research should examine the biological effects of the partially digested form-the CMP-derived fragments-rather than that of intact CMP.