[Interferon-regulating activity of the CelAgrip drug and its influence on the formation of reactive oxygen species and expression of innate immunity genes in Burkitt's lymphome cells cultures.]
Alexander N NarovlyanskyV V PoloskovA M IvanovaM V MezentsevaI A SuetinaL I RussuE S ChelarskayaA V Izmest'evaTatyana OspelnikovaI K ZubashevA A SarymsakovF I ErshovPublished in: Voprosy virusologii (2021)
In Namalva cells that do not produce EBV antigens the treatment of CA results in suppression of ROS generation and activation of the expression of genes ISG15 and P53 (TP53); in P3HR-1 cells producing EBV antigens, the opposite picture is observed - the formation of ROS and the expression of the IFN-α and IFN-λ genes are activated and the activity of the ISG15 and P53 (TP53) genes is suppressed.
Keyphrases
- induced apoptosis
- reactive oxygen species
- poor prognosis
- cell cycle arrest
- dendritic cells
- genome wide
- cell death
- epstein barr virus
- dna damage
- immune response
- bioinformatics analysis
- signaling pathway
- diffuse large b cell lymphoma
- dna methylation
- emergency department
- binding protein
- oxidative stress
- genome wide analysis
- replacement therapy