Xylobiose treatment strengthens intestinal barrier function by regulating Claudin 2 and Heat Shock Protein 27 expression in human Caco-2 cells.

Dina Mustika RiniYusuke NakamichiTomotake MoritaHiroyuki InoueYoichi MizukamiYoshinari YamamotoTakuya Suzuki

Published in: Journal of the science of food and agriculture (2023)

Our results revealed that xylobiose suppresses CLDN2 and increases HSP27 expression in intestinal Caco-2 cells via post-transcriptional regulation, potentially strengthening intestinal barrier integrity; however, these effects seem to occur via different signaling pathways. Our findings may help to assess the physiological role of xylobiose. This article is protected by copyright. All rights reserved.

Keyphrases

heat shock
induced apoptosis
signaling pathway
cell cycle arrest
heat shock protein
heat stress
poor prognosis
endoplasmic reticulum stress
oxidative stress
pi k akt
cell death
epithelial mesenchymal transition
single cell
smoking cessation
replacement therapy