Comparison of raw and regression approaches to capturing change on patient-reported outcome measures.
David A AndraeBrandon FosterJohn Devin PeipertPublished in: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (2022)
These results suggest that calculating change using regression estimates may result in more increased measurement sensitivity. Using these scores in lieu of raw differences can help better identify individuals who experience real underlying change in PROs in the course of a trial, and enhance the established methods for identifying thresholds for meaningful within-patient change in PROs.