IL-25 participates in keratinocyte-driven dermal matrix turnover and is reduced in systemic sclerosis epidermis.

Barbara RussoJulia BorowczykPietro CacialliPhilippe MogueletMarie-Elise TruchetetAli ModarressiNicolò C BrembillaJulien BertrandWolf-Henning BoehnckeCarlo Chizzolini

Published in: Rheumatology (Oxford, England) (2022)

These results show that IL-25 participates in skin homeostasis, and its decreased expression in SSc may contribute to skin fibrosis by favouring extracellular matrix deposition over degradation.

Keyphrases

systemic sclerosis
extracellular matrix
interstitial lung disease
wound healing
soft tissue
poor prognosis
bone mineral density
rheumatoid arthritis
binding protein
long non coding rna
idiopathic pulmonary fibrosis