Longitudinal changes in mitochondrial-associated measures and insulin resistance in youth with perinatally-acquired HIV in the U.S.
Greg S GojanovichWendy YuZhongli J ZhangDenise L JacobsonTzy-Jyun YaoJennifer JaoDaniel E LibuttiMitchell E GeffnerMariana Gerschensonnull nullPublished in: Mitochondrion (2024)
HIV infection and its treatment are associated with mitochondrial dysfunction and metabolic derangement. However, longitudinal changes in oxidative phosphorylation activities [Complex I (C1) and Complex IV (C4)], or venous lactate/pyruvate ratios (LPR), and their relationships with insulin resistance (IR), remain unclear in youth living with perinatally-acquired HIV (YPHIV). We measured venous LPR, C1, and C4 activities in blood cells and homeostatic model assessment for IR (HOMA-IR) over two years. Limited longitudinal differences in mitochondrial-related measures and IR were observed in YPHIV vs youth perinatally HIV-exposed but uninfected. There were no systematic differences in C1, C4, or HOMA-IR between the groups.
Keyphrases
- hiv infected
- antiretroviral therapy
- human immunodeficiency virus
- hiv positive
- hiv aids
- mental health
- insulin resistance
- physical activity
- young adults
- oxidative stress
- cross sectional
- induced apoptosis
- type diabetes
- metabolic syndrome
- polycystic ovary syndrome
- high fat diet
- men who have sex with men
- signaling pathway
- protein kinase
- south africa
- cell proliferation
- combination therapy
- weight loss