Microglial Activation and Progression of Nigrostriatal Dysfunction in Isolated REM Sleep Behavior Disorder.
Kristian StaerAlex IranzoMorten Gersel StokholmVictor Schwartz HvingelbyErik Hvid DanielsenKaren ØstergaardMónica SerradellMarit OttoKristina B SvendsenAlicia GarridoDolores VilasJoan SantamariaArne MøllerCarles GaigDavid J BrooksPer BorghammerEduardo TolosaNicola PavesePublished in: Movement disorders : official journal of the Movement Disorder Society (2024)
C-(R)-PK11195 binding have greater changes in nigrostriatal function, suggesting a detrimental rather than protective effect of microglial activation. Alternatively, both phenomena occur in patients with prominent nigrostriatal dysfunction without a causative link. The clinical and therapeutic implications of these findings need further elucidation. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.